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Alprazolam significantly improves the efficacy of granisetron in the prophylaxis of emesis secondary to moderately emetogenic chemotherapy in patients with breast cancer.

Author(s): Abali H, Oyan B, Guler N

Affiliation(s): S.B. Ankara Numune Hastanesi Tibbi Onkoloji Klinigi, Turkije. habali1970@yahoo.com

Publication date & source: 2005-08, Chemotherapy., 51(5):280-5. Epub 2005 Aug 12.

Publication type: Randomized Controlled Trial

BACKGROUND: Alprazolam, a newer benzodiazepine, may be useful in the control of nausea and vomiting in breast cancer patients. METHODS: Nineteen operable breast cancer patients were included in this randomized prospective crossover open-label trial. Patients received either granisetron (G) alone, or in combination with alprazolam (A). Group A patients received G+A first and then crossed over to G-alone after the 2nd or 3rd cycle. Group B patients received the reverse order. Eighty-four cycles were evaluated. RESULTS: In group A, complete remission (CR) plus major response (MR) was higher (93.9%) with G+A than with G-alone (83.3%; p = 0.0001) in the first 24-hour period. In group B, CR plus MR was higher in G+A cycles (100%) than in G-alone cycles (85.7%; p = 0.035) in the 24-hour period and in the 25- to 129-hour period (92 vs. 90.5%, respectively; p = 0.022). CONCLUSION: Alprazolam increases the efficacy of granisetron in patients with breast cancer treated with an anthracycline-containing regimen.

Page last updated: 2006-01-31

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