Effectiveness of topical curcumin for treatment of mastitis in breastfeeding
women: a randomized, double-blind, placebo-controlled clinical trial.
Author(s): Afshariani R(1), Farhadi P(2), Ghaffarpasand F(3), Roozbeh J(4).
Affiliation(s): Author information:
(1)Assistant Professor of Neonatology, Department of Public Health, School of Health
and Nutrition, Shiraz University of Medical Sciences, Shiraz, Iran.
(2)Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
(3)Resident of Neurosurgery, Shiraz University of Medical Sciences; Neuroscience
Research Center, Chamran Hospital, Chamran Avenue, Shiraz, Iran. Postal Code:
7194815644.
(4)Professor of Nephrology, Nephrology-Urology Research Center, Shiraz University of
Medical Sciences, Shiraz, Iran.
Publication date & source: 2014, Oman Med J. , 29(5):330-4
OBJECTIVE: To determine the efficacy of topical curcumin in reducing breast
inflammation in women suffering from lactational mastitis.
METHODS: A randomized double-blind, placebo-controlled study including 63
breastfeeding women with lactational mastitis were randomly assigned to receive
curcumin topical cream, one pump every 8 hours for 3 days (n=32) or topical
moisturizer as placebo (n=31). Using an index for severity of breast
inflammation, all of the patients had moderate breast inflammation before
entering the study. The outcome of treatment was evaluated using the same index
at 24, 48 and 72 hours of starting the treatment.
RESULTS: There was no significant difference between two study groups regarding
the baseline characteristics such as age (p=0.361) and duration of lactation
(p=0.551). After 72-hour of therapy, patients in curcumin groups had
significantly lower rate of moderate (p=0.019) and mild (p=0.002) mastitis.
Patients in curcumin group had significantly lower scores for tension (p<0.001),
erythema (p<0.001) and pain (p<0.001), after 72-hour of treatment.
CONCLUSION: The results of the current study indicate that topical preparation of
curcumin successfully decrease the markers of lactational mastitis such as pain,
breast tension and erythema within 72 hours of administration without side
effects. Thus, topical preparation of curcumin could be safely administered for
those suffering from lactational mastitis after excluding infectious etiologies.
|
