Comparative evaluation of effect of preoperative oral medication of ibuprofen and
ketorolac on anesthetic efficacy of inferior alveolar nerve block with lidocaine
in patients with irreversible pulpitis: a prospective, double-blind, randomized
clinical trial.
Author(s): Aggarwal V, Singla M, Kabi D.
Affiliation(s): Department of Dental Surgery, Safdarjung Hospital, New Delhi, India.
drvivekaggarwal@gmail.com
Publication date & source: 2010, J Endod. , 36(3):375-8
INTRODUCTION: Anesthetic efficacy of inferior alveolar nerve block decreases in
patients with irreversible pulpitis. It was hypothesized that premedication with
nonsteroidal anti-inflammatory drugs might improve the success rates in patients
with inflamed pulps.
METHODS: Sixty-nine adult volunteers who were actively experiencing pain
participated in this prospective, randomized, double-blind study. The patients
were divided into 3 groups on a random basis and were randomly given 1 of the 3
drugs including ibuprofen, ketorolac, and placebo 1 hour before anesthesia. All
patients received standard inferior alveolar nerve block of 2% lidocaine with
1:200,000 epinephrine. Endodontic access preparation was initiated after 15
minutes of initial inferior alveolar nerve block. Pain during treatment was
recorded by using a Heft Parker visual analog scale. Success was recorded as none
or mild pain.
RESULTS: Statistical analysis with nonparametric chi2 tests showed that placebo
gave 29% success rate. Premedication with ibuprofen gave 27%, and premedication
with ketorolac gave 39% success rate. There was no significant difference between
the 3 groups.
CONCLUSIONS: Preoperative administration of ibuprofen or ketorolac has no
significant effect on success rate of inferior alveolar nerve block in patients
with irreversible pulpitis.
|