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Scopolamine augments transient auditory 40-hz magnetic response in humans.

Author(s): Ahveninen J, Tiitinen H, Hirvonen J, Pekkonen E, Huttunen J, Kaakkola S, Jaaskelainen IP

Affiliation(s): Department of Psychology, University of Helsinki, Finland. jyrki.ahveninen@helsinki.fi

Publication date & source: 1999-12-24, Neurosci Lett., 277(2):115-8.

Publication type: Clinical Trial; Randomized Controlled Trial

The influence of neocortical muscarinic transmission on auditory-evoked 40-Hz magnetic response was studied in 13 healthy subjects in a double-blind randomized cross-over design. Either a centrally (scopolamine hydrobromide, 0.3 mg, i.v.) or a peripherally (glycopyrrolate, 0.2 mg, i.v.) acting antagonist of muscarinic transmission was administered during two sessions of magnetoencephalographic recording of 40-Hz response elicited by monaural tones. Scopolamine significantly (P < 0.01) augmented the 40-Hz magnetic response over the hemispheres ipsi- and contralateral to the ear stimulated. This finding suggests muscarinic modulation of the auditory evoked transient 40-Hz response.

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