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Acute immune thrombocytopenic purpura: a comparative study of very high oral doses of methylprednisolone and intravenously administered immune globulin.

Author(s): Albayrak D, Islek I, Kalayci AG, Gurses N

Affiliation(s): Department of Pediatric Hematology, Medical Faculty of Ondokuzmayis University, Samsun, Turkey.

Publication date & source: 1994-12, J Pediatr., 125(6 Pt 1):1004-7.

Publication type: Clinical Trial; Randomized Controlled Trial

We compared very high doses of methylprednisolone with intravenously administered immune globulin for treatment of acute idiopathic thrombocytopenic purpura. Fifty-seven children were randomly assigned to receive the immune globulin preparation, 0.5 gm/kg per day for 5 consecutive days (n = 19), orally administered methylprednisolone, 30 mg/kg per day for 7 days (n = 19), or orally administered methylprednisolone, 50 mg/kg per day for 7 days (n = 19). There were no differences in the response of the platelet counts among the groups. We conclude that these two therapies were equally effective; choice between them may be made according to cost and therapy-related risks.

Page last updated: 2006-01-31

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