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Serologically documented loracarbef (Lorabid)-induced immune thrombocytopenia.

Author(s): Aljitawi OS, Krishnan K, Curtis BR, Bougie DW, Aster RH

Affiliation(s): Division of Hematology/Oncology and Department of Internal Medicine, James H. Quillen College of Medicine, East Tennessee State University, Building 1, Dogwood Avenue, Johnson City, TN 37614, USA.

Publication date & source: 2003-05, Am J Hematol., 73(1):41-3.

Publication type: Case Reports; Research Support, U.S. Gov't, P.H.S.

We report here the first case of severe immune thrombocytopenia induced by a second-generation cephalosporin antibiotic, Loracarbef. A 56-year old white female developed acute severe thrombocytopenia associated with acute respiratory symptoms following administration of Loracarbef. She responded to Loracarbef withdrawal and systemic corticosteroid administration. Loracarbef-dependent platelet-reactive antibodies were demonstrable in her serum by flow cytometry. Copyright 2003 Wiley-Liss, Inc.

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