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[Efficacy of prednisolone and rimexolone in HLA-B27 positive patients with acute anterior uveitis]

Author(s): Arellanes-Garcia L, Padilla-Aguilar G, Navarro-Lopez P, Espinoza-Martinez C

Affiliation(s): Clinica de Enfermedades Inflamatorias Oculares, Hospital Dr Luis Sanchez Bulnes de la Asociacion para Evitar la Ceguera en Mexico, Coyoacan. agml@servidor.unam.mx

Publication date & source: 2005-09, Gac Med Mex., 141(5):363-6.

Publication type: Randomized Controlled Trial

PURPOSE: To compare the efficacy and safety of prednisolone acetate 1% vs. rimexolone 1% ophthalmic suspension in the treatment of acute anterior uveitis (AAU) in HLA-B27+ patients. METHODS: Sixty-eight AAU HLA-B27+ patients were randomly selected for treatment with prednisolone acetate 1% or Rimexolone 1%. All patients showed mild to moderate anterior chamber inflammation. This was a prospective, randomized, double blind, clinical trial. RESULTS: There was no statistically significant difference between both groups when anterior chamber cells were measured. In the rimexolonae group, flare diminished since the first week. In both groups the intraocular pressure (IOP) raised since the first week, the increase was highly significant in the rimexolone group. Final intraocular pressure was higher in the prednisolone group. CONCLUSION: Rimexolone 1% is as effective as prednisolone acetate 1% in the treatment of mild to moderate AAU HLA-B27+. IOP increased in both groups, but this variation was not clinically significant.

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