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Differences in the immune response to hepatitis B and Haemophilus influenzae type b vaccines in Guatemalan infants by ethnic group and nutritional status.

Author(s): Asturias EJ, Mayorga C, Caffaro C, Ramirez P, Ram M, Verstraeten T, Clemens R, Halsey NA

Affiliation(s): Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, United States. easturia@jhsph.edu

Publication date & source: 2009-06-02, Vaccine., 27(27):3650-4. Epub 2009 Apr 7.

Publication type: Randomized Controlled Trial; Research Support, Non-U.S. Gov't

Ladino and native Indian Guatemalan infants developed high rates (96-100%) of protective antibodies after receiving conjugate Haemophilus influenzae type b and hepatitis B vaccines at 2, 4 and 6 months of age. Native Indian infants developed significantly (p<0.01) higher geometric mean anti-PRP (polyribose-ribitol-phosphate) and anti-HBs (anti-hepatitis b surface) antibody concentrations than Ladino infants. Malnourished infants generally responded as well as healthy infants. Unvaccinated native Indian infants had higher rates of developing anti-PRP antibodies than Ladino infants by seven months of age.

Page last updated: 2009-10-20

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