The efficacy, safety, and tolerability of adapalene versus benzoyl peroxide in
the treatment of mild acne vulgaris: a randomized trial.
Author(s): Babaeinejad SH(1), Fouladi RF.
Affiliation(s): Author information:
(1)Department of Dermatology, Tabriz University of Medical Sciences, Sina Hospital,
Tabriz, Iran.
Publication date & source: 2013, J Drugs Dermatol. , 12(7):790-4
Topical treatments, such as adapalene and benzoyl peroxide (BPO), are popular in
mild-to-moderate acne vulgaris. This study aimed to compare the efficacy, safety
and tolerability of adapalene and BPO in mild acne vulgaris. In this
single-center, randomized, double-blind, clinical trial, 60 patients with mild
acne vulgaris received either topical adapalene 0.1% gel or topical BPO 2.5% gel
on their face once daily for two months. The changes of acne lesion count
(efficacy), any adverse effect (safety), and the patients' overall satisfaction
(tolerability) were compared after 3 months of follow-up. In both groups the mean
number of noninflammatory, inflammatory and total lesions decreased significantly
from baseline (10.77±5.54, 9.73±5.09, and 20.50±7.54, respectively in adapalene
group; 11.50±5.92, 8.43±5.45, and 19.93±9.01, respectively in BPO group) to the
third month (1.70±1.68, 0.33±0.66, and 0.50±0.78, respectively in adapalene
group; 4.23±4.14, 0.33±0.71, and 4.13±4.44, respectively in BPO group; P<0.001
for all), posttreatment. Although the mean number of inflammatory lesions was
significantly lower in BPO receivers only at first month (P =0.001), the mean
number of noninflammatory and total lesions was significantly lower in adapalene
group at second (P = 0.04 and 0.03, respectively) and third (P =0.02 and <0.001,
respectively) months, posttreatment. The adverse events were minimal and
self-limited (26.7% in adapalene group, 20% in BPO group, p=0.54). The patients'
overall satisfaction was good to excellent in 93.3% of adapalene receivers vs.
73.3% in BPO group (P=0.08). Both topical adapalene 0.1% and BPO 2.5% gels seem
safe and effective in mild acne vulgaris, with a marginal tendency toward the
former.
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