DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more



Furosemide for packed red cell transfusion in preterm infants: a randomized controlled trial.

Author(s): Balegar V KK, Kluckow M

Affiliation(s): Department of Neonatology, Royal North Shore Hospital, Sydney, Australia.

Publication date & source: 2011-12, J Pediatr., 159(6):913-918.e1. Epub 2011 Jul 23.

OBJECTIVE: To assess the effect of furosemide administered with packed red blood cell transfusion on cardiopulmonary variables of hemodynamically stable, electively transfused preterm infants beyond the first week of life. STUDY DESIGN: A randomized, stratified, double-blind, placebo-controlled trial of intravenous furosemide (1 mg/kg) versus placebo (normal saline) just before "top-up" packed red blood cell transfusion (20 mL/kg over 4 hours) in a tertiary neonatal intensive care unit. RESULTS: The primary outcome was a change in fraction of inspired oxygen (FiO(2)) during the 24 hours posttransfusion compared with the 6-hour pretransfusion period. Secondary outcomes were functional echocardiographic and clinical/biochemical variables. Of 51 consecutive preterm infants with mean (+/- SD) birth weights of 900 g (+/- 28); enrollment weights of 1342 g (+/- 432); birth gestation of 27 weeks (+/- 1); and postmenstrual age of 32 weeks (+/- 4), 40 completed the study. Pretransfusion variables were comparable between the furosemide (n = 21) and placebo (n = 19) groups. There was a small but significant increase (P < .05) in posttransfusion FiO(2) in placebo (relative increase of 7%, equivalent to an absolute increase from 0.27 to 0.29) compared with the furosemide group. Other variables were similar. No infant received open-label furosemide. CONCLUSIONS: Routine furosemide in electively transfused preterm infants confers minimal clinical benefits. Prevention of a clinically insignificant FiO(2) rise needs to be balanced against potential adverse effects. Copyright (c) 2011 Mosby, Inc. All rights reserved.

Page last updated: 2011-12-09

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017