Perioperative cefazolin prophylaxis in hip fracture surgery.

Author(s): Buckley R, Hughes GN, Snodgrass T, Huchcroft SA

Affiliation(s): Department of Surgery, University of Calgary, Alta.

Publication date & source: 1990-04, Can J Surg., 33(2):122-7.

Publication type: Clinical Trial; Randomized Controlled Trial

Antibiotics given perioperatively are thought to decrease the occurrence of postoperative wound infection. The duration of treatment for hip fracture surgery is empirical. This randomized, double-blind, single-hospital clinical study was carried out to assess the effect of both antibiotic use and duration of use on wound infections in hip fracture surgery. Wound infection rates in three groups of patients were compared: those who received four doses of cefazolin (108 patients), those who received one dose of cefazolin and three doses of placebo (83 patients) and those who received four placebo doses (121 patients). Results showed an infection rate of 1.6% for the four-dose group, 2.4% for the one-dose group and 3.7% for the placebo group. These differences were not statistically significant, even when both treatment groups were combined and compared with the placebo group. The authors conclude that until more patients are added, empirical use of antibiotics should be continued in patients who undergo hip fracture surgery.