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Helicobacter pylori chronic gastritis in children: to eradicate or not to eradicate?

Author(s): Buonavolonta R, Miele E, Russo D, Vecchione R, Staiano A

Affiliation(s): Department of Pediatrics, University Federico II, Naples, Italy.

Publication date & source: 2011-07, J Pediatr., 159(1):50-6. Epub 2011 Mar 10.

Publication type: Randomized Controlled Trial

OBJECTIVE: To evaluate the efficacy of triple eradication therapy versus symptomatic therapy in children with Helicobacter pylori-associated chronic active gastritis (H pylori-ACAG). STUDY DESIGN: Symptomatic patients with H pylori-ACAG (n=31) were randomly assigned into two groups: (1) patients infected with H pylori who were treated with triple eradication therapy (n = 16); and (2) patients infected with H pylori who were treated with symptomatic therapy (n=15). RESULTS: After 1 year of follow-up, macroscopic appearance was significantly different in group B (P=.023), and chronic inflammation, H Pylori density, and activity were significantly higher in group B than in group A (P=.022, .007, and .002, respectively); however, we did not find a significant difference in the symptoms comparing both groups (P=.287). After 1 year of follow-up, we observed the persistence of the H pylori infection in all children who had not received eradication treatment. CONCLUSIONS: There is no correlation between eradication of H pylori infection and improvement of dyspeptic symptoms. Self-eradication does not occur within 1 year of follow-up. A trend toward a higher rate of chronic inflammation in noneradicated children at 1 year limited the time of our study. Copyright (c) 2011 Mosby, Inc. All rights reserved.

Page last updated: 2011-12-09

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