DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Three-dose vs extended-course clindamycin prophylaxis for free-flap reconstruction of the head and neck.

Author(s): Carroll WR, Rosenstiel D, Fix JR, de la Torre J, Solomon JS, Brodish B, Rosenthal EL, Heinz T, Niwas S, Peters GE

Affiliation(s): Division of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham, 35233, USA. William.Carroll@ccc.uab.edu

Publication date & source: 2003-07, Arch Otolaryngol Head Neck Surg., 129(7):771-4.

Publication type: Clinical Trial; Randomized Controlled Trial

BACKGROUND: Twenty-four hours of perioperative antibiotics provides effective prophylaxis for most head and neck cancer resections. Many reconstructive surgeons have been hesitant to apply this standard to free-flap reconstruction of the head and neck. This prospective clinical trial compared short-course and long-course clindamycin prophylaxis for wound infection in patients with head and neck cancer undergoing free-flap reconstruction. METHODS: Seventy-four patients were randomized to receive short-course (3 doses) or long-course (15 doses) clindamycin perioperatively. Wound infections, fistulas, and other postoperative complications were documented by faculty surgeons who were blinded as to treatment group. RESULTS: The differences in wound infections and other complications were statistically insignificant. No other independent predictors of wound complications emerged in this series of patients. CONCLUSIONS: Short-course clindamycin is as effective as long-course clindamycin in preventing wound infections after free-flap surgery for head and neck ablative defects.

Page last updated: 2006-01-31

-- advertisement -- The American Red Cross
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017