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Salvage therapy with tigecycline for recurrent infection caused by ertapenem-resistant extended-spectrum beta-lactamase-producing Klebsiella pneumoniae.

Author(s): Chen PL, Yan JJ, Wu CJ, Lee HC, Chang CM, Lee NY, Ko NY, Wang LR, Shih HI, Lee CC, Ko WC

Affiliation(s): Department of Medicine, National Cheng Kung University Medical College, Tainan, Taiwan.

Publication date & source: 2010-11, Diagn Microbiol Infect Dis., 68(3):312-4. Epub 2010 Sep 16.

Publication type: Case Reports

Optimal antimicrobial therapy for infections due to ertapenem-resistant Enterobacteriaceae remains undetermined. In this study, a diabetic patient with recurrent pyomyositis and osteomyelitis caused by extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae developed ertapenem resistance after imipenem/cilastatin treatment, which was a currently recommended therapy. He was finally treated successfully using tigecycline. Ertapenem resistance was in part explained by the production of SHV-type ESBL and the absence of an outer membrane protein, OmpK36. Our observation suggests that tigecycline may be an alternative for invasive infections caused by ESBL-producing Enterobacteriaceae with decreased susceptibility to carbapenem. Copyright (c) 2010 Elsevier Inc. All rights reserved.

Page last updated: 2011-12-09

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