Vitamin D and nifedipine in the treatment of Chinese patients with grades I-II
essential hypertension: a randomized placebo-controlled trial.
Author(s): Chen WR(1), Liu ZY(1), Shi Y(2), Yin da W(1), Wang H(1), Sha Y(1), Chen YD(3).
Affiliation(s): Author information:
(1)Department of South-Building Cardiology, PLA General Hospital at Beijing, Beijing
100853, China.
(2)Department of South-Building Cardiology, PLA General Hospital at Beijing, Beijing
100853, China. Electronic address: chen_weiren@sina.com.
(3)Department of Cardiology, PLA General Hospital at Beijing, Beijing 100853, China.
Publication date & source: 2014, Atherosclerosis. , 235(1):102-9
OBJECTIVES: Low vitamin D status has been shown to be associated with
hypertension. We planned to research the effect of vitamin D and nifedipine in
the treatment of patients with essential hypertension.
METHODS: Patients with grades I-II essential hypertension were enrolled in this
single-center, double-blind, placebo-controlled trial in Beijing. All patients
received a conventional antihypertensive drug (nifedipine, 30 mg/d). One hundred
and twenty-six patients were randomly assigned to receive vitamin D (n=63, 2000
IU/d) or a placebo (n=63) as an add-on to nifedipine, by the method of permutated
block randomization. Ambulatory blood pressure monitoring was performed at
baseline (month 0), at month 3 and at month 6.
RESULTS: In vitamin D supplementation group, there was a significant increase in
mean 25-hydroxyvitamin D levels from baseline (19.4 ± 11.6 ng/ml) to 6 months
(34.1 ± 12.2 ng/ml; p<0.001). At 6 months, the primary end points, a difference
in the fall of 24-h mean blood pressure, between the groups was -6.2 mmHg (95% CI
-11.2; -1.1) for systolic blood pressure (p<0.001) and -4.2 mmHg (95% CI -8.8;
-0.3) for diastolic blood pressure (p<0.001) under intention to treat analysis.
In patients with vitamin D <30 ng/ml at baseline (n=113), 24-h mean blood
pressure decreased by 7.1/5.7 mmHg (p<0.001). Safety and tolerability were
similar among the two groups.
CONCLUSIONS: Vitamin D supplementation can reduce blood pressure in patients with
hypertension, it can be an adjuvant therapy for patients with grades I-II
essential hypertension. Clinical Trial Registration: This study was registered in
the Chinese Clinical Trial Registry, it is available in Website:
http://www.chictr.org/cn/; Registration number: ChiCTR-ONC-13003840.
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