Topical piperacillin/tazobactam for recalcitrant pseudomonas aeruginosa keratitis.

Author(s): Chew FL, Soong TK, Shin HC, Samsudin A, Visvaraja S

Affiliation(s): Department of Ophthalmology, Faculty of Medicine, University of Malaya, Jalan Universiti, Kuala Lumpur, Wilayah Persekutuan 50603, Malaysia. sabrefmin@yahoo.co.uk

Publication date & source: 2010-04, J Ocul Pharmacol Ther., 26(2):219-22.

Publication type: Case Reports

PURPOSE: To report the treatment of therapy-resistant Pseudomonas aeruginosa keratitis with topical piperacillin/tazobactam. METHODS: Retrospective report of 3 cases. RESULTS: Three patients with P. aeruginosa keratitis were unresponsive to various antimicrobials. Resolution of all 3 cases of keratitis occurred upon commencement of topical piperacillin/tazobactam. CONCLUSION: Therapy-resistant P. aeruginosa keratitis acquired from the community is becoming an increasing problem. Topical piperacillin/tazobactam is an option for the treatment of therapy-resistant P. aeruginosa keratitis.