Pre-emptive analgesia with pregabalin and celecoxib decreases postsurgical pain
following maxillomandibular advancement surgery: a randomized controlled clinical
trial.
Author(s): Cillo JE Jr(1), Dattilo DJ(2).
Affiliation(s): Author information:
(1)Assistant Professor and Program Director, Division of Oral and Maxillofacial
Surgery, Allegheny General Hospital, Allegheny Health Network, Pittsburgh, PA.
Electronic address: jecdna@aol.com.
(2)Division Director, Division of Oral and Maxillofacial Surgery, Allegheny General
Hospital, Allegheny Health Network, Pittsburgh, PA.
Publication date & source: 2014, J Oral Maxillofac Surg. , 72(10):1909-14
PURPOSE: The purpose of this study was to determine the efficacy of pre-emptive
analgesia with pregabalin and celecoxib on narcotic consumption and perceived
pain in adult patients undergoing maxillomandibular advancement surgery for
obstructive sleep apnea.
PATIENTS AND METHODS: This was a prospective, randomized, double-blinded,
placebo-controlled study of adult patients undergoing elective maxillomandibular
advancement surgery for obstructive sleep apnea. The groups received a masked
1-time preoperative oral dose of pregabalin 150 mg and celecoxib 400 mg
(experimental group) or lactose powder 2 g (placebo group). In the postoperative
period, pain management consisted of intravenous morphine patient-controlled
analgesia and oral oxycodone 5 mg and acetaminophen 325 mg. Patients completed a
daily pain and narcotic log. Statistical significance between group means was
determined by the 2-tailed independent t test.
RESULTS: There were statistically significant differences between the pregabalin
plus celecoxib and placebo groups in average intravenous morphine consumption per
4-hour interval (6.0 ± 5.9 vs 9.3 ± 7.9 mg; P < .05), mean daily narcotic pill
consumption (2.9 ± 2.9 vs 6.8 ± 1.8 pills; P < .05), and mean daily visual analog
scale scores (4.3 ± 3.5 vs 5.5 ± 5.0; P < .05).
CONCLUSION: Within the limitations of this study, a 1-time preoperative oral dose
of pregabalin and celecoxib before adult maxillomandibular advancement surgery
for obstructive sleep apnea decreased mean intravenous morphine consumption, mean
daily narcotic pill consumption, and mean patient perceived pain.
|