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A Randomised Study of Two Doses of Biosynthetic Human Growth Hormone on Final Height of Pubertal Children with Growth Hormone Deficiency.

Author(s): Coelho R, Brook CG, Preece MA, Stanhope RG, Dattani MT, Hindmarsh PC

Affiliation(s): Great Ormond Street Hospital for Children NHS Trust, and University College Hospital, London, UK.

Publication date & source: 2008-06-12, Horm Res., 70(2):85-88 [Epub ahead of print]

Aims: To determine the effectiveness of different doses of r-hGH therapy during puberty in children with growth hormone deficiency (GHD). Methods: Randomized controlled trial of different doses of r-hGH therapy administered during puberty in 49 children with GHD. The patients were allocated randomly using a random number table to one of two groups: group 1 (15 IU/m(2)/week) or group 2 (30 IU/m(2)/week). Patients were included if they had received r-hGH daily at a dose of 15 IU/m(2)/week (0.7 mg/m(2)/day) for at least 1 year before randomization. Results: Height increase standard deviation scores (SDS) were similar between the two groups (group 1: 1.1; group 2: 1.2; p = 0.81). Conclusion: A higher dose of r-hGH administered during puberty does not appear to have a significant effect on final height of children with GH deficiency. Altering pubertal tempo or intensifying prepubertal r-hGH therapy may be a more promising approach to improving final height in children with GH deficiency. Copyright (c) 2008 S. Karger AG, Basel.

Page last updated: 2008-06-22

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