A comparison of oxycodone prolonged-release vs. oxycodone + naloxone
prolonged-release after laparoscopic hysterectomy.
Author(s): Comelon M(1), Wisloeff-Aase K, Raeder J, Draegni T, Undersrud H, Qvigstad E,
Bjerkelund CE, Lenz H.
Affiliation(s): Author information:
(1)Department of Anaesthesiology - Ullevaal, Oslo University Hospital, Oslo, Norway.
marlin.comelon@gmail.com
Publication date & source: 2013, Acta Anaesthesiol Scand. , 57(4):509-17
BACKGROUND: Targiniq®, an oxycodone prolonged-release (PR) formulation combined
with the opioid antagonist naloxone PR, aims to prevent opioid-induced
constipation without impairing the analgesic efficacy. This has been confirmed
during prolonged use in chronic pain or cancer patients. The purpose of our study
was to compare clinical effects of oxycodone PR with oxycodone PR + naloxone PR
for short-term post-operative pain management.
METHODS: This randomised, double-blind, prospective study included 85 women
undergoing laparoscopic hysterectomy. The two groups received either oxycodone PR
10 mg or oxycodone PR 10 mg + naloxone PR 5 mg as pre-medication and twice daily
for 3 days. As rescue analgesic, the patients received oxycodone intravenous
during the first 24 h post-operatively and oxycodone tablets in the 24-72-h
period. Constipation, other side effects, pain and satisfaction were registered
during the first 7 post-operative days.
RESULTS: Demographic, pre- and perioperative variables and the use of rescue
analgesics were similar in the groups. There were no significant differences in
variables related to constipation. In the oxycodone PR + naloxone PR group, 25%
had no defecation during the first 72 h post-operatively, compared with 20% in
the oxycodone PR group (mean 1.2 ± 1.1 vs. 2.1 ± 2.4 defecations). Other
opioid-induced effects and side effects showed no significant differences. Only
7% were dissatisfied with their oral pain treatment.
CONCLUSION: Addition of naloxone to oxycodone PR tablets in a pain regimen
administered twice daily the first three post-operative days had no significant
clinical effects on constipation or other variables during the first week after
hysterectomy.
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