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Linear IgA disease: successful treatment with erythromycin.

Author(s): Cooper SM, Powell J, Wojnarowska F

Affiliation(s): Department of Dermatology, Oxford Radcliffe Hospitals, Oxford, UK. sm_nc@btopenworld.com

Publication date & source: 2002-11, Clin Exp Dermatol., 27(8):677-9.

Publication type: Case Reports

Conventional first-line treatments for linear IgA disease (and the related chronic immunobullous disease of childhood) include topical steroids and dapsone, both of which may be associated with potentially serious side-effects. Alternative anti-inflammatory therapies such as tetracycline and macrolide antibiotics, have been used to treat other immunobullous disorders and we now report an adult case of linear IgA disease and a paediatric case of mixed immunobullous disease of childhood that both responded to the macrolide antibiotic erythromycin. The mode of action is speculative and anti-inflammatory mechanisms are unclear. Nevertheless, from a clinical perspective, erythromycin may have a role in the treatment of linear IgA disease and could be considered ahead of many other, perhaps potentially more toxic, therapies.

Page last updated: 2006-01-31

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