Single Dose Corticosteroid Therapy After Surgical Repair of Fallot's Tetralogy; A
Randomized Controlled Clinical Trial.
Author(s): Dalili M(1), Vesal A(1), Tabib A(1), Khani-Tafti L(2), Hosseini S(1), Totonchi
Z(1).
Affiliation(s): Author information:
(1)Rajaie Cardiovascular Medical and Research Center, Iran University of Medical
Sciences, Tehran, IR Iran. (2)Echocardiography Research Center, Rajaie
Cardiovascular Medical and Research Center, Iran University of Medical Sciences,
Tehran, IR Iran.
Publication date & source: 2015, Res Cardiovasc Med. , 4(1):e25500
BACKGROUND: Inflammatory reaction can produce several complications after cardiac
surgery. Many attempts have been made to reduce these complications;
perioperative corticosteroid therapy is one of the simplest methods.
OBJECTIVES: We conducted a randomized study to evaluate the efficacy of single
dose methylprednisolone, prescribed after surgery, for reducing the
complications. Repair of Tetralogy of Fallot was chosen as a homogenous large
group for the study.
PATIENTS AND METHODS: One hundred children who underwent total repair of
Tetralogy of Fallot were enrolled in this study. After the surgery, all patients
were transferred to pediatric ICU and were randomized (in a double-blind fashion)
in 2 groups (A and B); a single dose of methylprednisolone (30 mg/kg of body
weight) was injected to participants of group "A" just at the time of ICU
entrance. Group "B" received no drug. Then, clinical outcomes and laboratory data
were compared between the two groups.
RESULTS: The only significant differences were lower incidence of bacteremia and
higher incidence of hyperglycemia in the group who were used methylprednisolone.
CONCLUSIONS: Using a single postsurgical dose of methylprednisolone does not
significantly alter the clinical outcome after repairing Tetralogy of Fallot.
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