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Design and organization of the herpetic eye disease study (HEDS).

Author(s): Dawson CR, Jones DB, Kaufman HE, Barron BA, Hauck WW, Wilhelmus KR

Affiliation(s): Francis I. Proctor Foundation, University of California, San Francisco.

Publication date & source: 1991, Curr Eye Res., 10 Suppl:105-10.

Publication type: Clinical Trial; Multicenter Study; Randomized Controlled Trial

The Herpetic Eye Disease Study (HEDS) includes three double-masked, placebo-controlled clinical trials for potentially blinding herpes simplex virus (HSV) eye infections. One study compares a tapering dosage of topical prednisolone or placebo eye drops for HSV stromal keratitis (HEDS-SKN). Two other trials compare oral acyclovir to placebo capsules for HSV stromal keratitis (HEDS-SKS) or iridocyclitis (HEDS-IRT) in patients on a tapering dosage of topical prednisolone drops. All medications are administered for 10 weeks. Outcome is judged by time to recurrent disease or treatment failure. This paper presents the design, estimated sample size and recruitment as of July 25, 1990.

Page last updated: 2006-01-31

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