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A comparison of the postoperative analgesic efficacy of single-dose epidural tramadol versus morphine in children.

Author(s): Demiraran Y, Kocaman B, Akman RY

Affiliation(s): Department of Anesthesiology, Duzce School of Medicine, Abant Izzet Baysal University, Turkey. demiryvz@yahoo.com

Publication date & source: 2005-10, Br J Anaesth., 95(4):510-3. Epub 2005 Aug 12.

Publication type: Clinical Trial; Randomized Controlled Trial

BACKGROUND: The aim of this study was to compare epidural administration of single-dose tramadol with morphine in children undergoing urological surgery with respect to preoperative haemodynamic effects, postoperative analgesia and side-effects. METHODS: Eighty children aged between 7 and 14 undergoing urological surgery were included in the study. After intubation, in the lateral decubitus position, a single dose of morphine 0.1 mg kg(-1) in isotonic saline 0.2 ml kg(-1) (morphine group) and tramadol 2 mg kg(-1) in isotonic saline 0.2 ml kg(-1) (tramadol group) was administered epidurally. During the 24-h postoperative period, heart rate, systolic blood pressure, respiration rate, pain score and sedation level of the patients were monitored. A modified objective pain score of 3 or lower was accepted as an indicator of inadequate analgesia and these patients were given 20 acetaminophen mg kg(-1) rectally or orally. Time to first analgesia was noted. Sedation level was evaluated with a four-point sedation scale. RESULTS: In the postoperative period, pain scores and the average time for analgesic requirement were similar in the two groups. However, the incidences of allergic rash, itching, sedation and respiratory depression and sedation score were greater in the morphine group than in the tramadol group. CONCLUSION: Greater epidural use of tramadol may be preferred to morphine for postoperative analgesia under these circumstances.

Page last updated: 2006-01-31

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