[Comparisons of efficacy and safety of tolterodine and oxybutynin in children with idiopathic overactive bladder].

Author(s): Deng YJ, Ma G, Guo YF, Ge Z, Lu RG, Wang LX, Zhu HB, Chen CJ

Affiliation(s): Department of Urology, Nanjing Children's Hospital Affiliated to Nanjing Medical University, Nanjing 210008, China.

Publication date & source: 2011-01, Zhongguo Dang Dai Er Ke Za Zhi., 13(1):26-8.

Publication type: Comparative Study; English Abstract; Randomized Controlled Trial

OBJECTIVE: To compare the efficacy and safety of tolterodine and oxybutynin in the treatment of idiopathic overactive bladder in children. METHODS: A total of 204 children with idiopathic overactive bladder were randomly divided into three groups (n=68 each): placebo, tolterodine-treated and oxybutynin-treated. The efficacy and safety were evaluated two weeks after treatment. RESULTS: The effective rate was 25% in the placebo group, 89% in the tolterodine-treated group, and 92% in the oxybutynin-treated group. The effective rate in the two treatment groups was significantly higher than that in the placebo group (P<0.05). There was a similar efficacy between the two treatment groups. The incidence of adverse events in the tolterodine-treated group (28%) was significantly lower than that in the oxybutnin-treated group (57%) (P<0.05). CONCLUSIONS: Tolterodine has a similar efficacy to oxybutynin in the treatment of idiopathic overactive bladder in children, with better safety in pharmacotherapy.