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Bioactive polymers: in vitro and in vivo study of controlled release neomycin.

Author(s): Dumitriu S, Dumitriu M, Dimitriu SM, Turcu T, Grigore L, Dumitriu D, Iacob M

Affiliation(s): Polytechnic Institute of Jassy, Department of Macromolecular Chemistry, Romania.

Publication date & source: 1992-01, J Biomater Appl., 6(3):251-60.

Publication type: Clinical Trial; Comparative Study ; Randomized Controlled Trial

Neomycin is coupled on xanthan-a polysaccharide of microbial biosynthesis produced by Xanthomonas campestris-through ionic complexation. The kinetics of neomycin release, in vitro, at pH = 8.2 is studied. A controlled release of neomycin, following a zero order kinetics is observed, regardless of the eluent flow. Neomycin complexed on xanthan, administered in a unique daily dose to patients suffering from dysentery in the 100 cases taken in study, has shown a high clinical efficiency as compared with the treatments with ampicillin or furazolidone, administered for 5-10 days or longer.

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