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Lack of efficacy of tacrolimus ointment 0.1% for treatment of hemodialysis-related pruritus: a randomized, double-blind, vehicle-controlled study.

Author(s): Duque MI, Yosipovitch G, Fleischer AB Jr, Willard J, Freedman BI

Affiliation(s): Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA.

Publication date & source: 2005-03, J Am Acad Dermatol., 52(3 Pt 1):519-21.

Publication type: Clinical Trial; Randomized Controlled Trial

Pruritus is a common and disabling symptom for patients undergoing hemodialysis. Many topical and systemic treatments have been used for uremic pruritus, mostly in anecdotal reports. A recent case series demonstrated that topical tacrolimus ointment 0.03% had a significant antipruritic effect for patients with uremia. In an attempt to confirm these findings, we conducted a randomized, double-blind, vehicle-controlled study to assess the efficacy of tacrolimus ointment 0.1% for the treatment of hemodialysis-related pruritus. The results of this study do not demonstrate that tacrolimus ointment 0.1% is more effective than vehicle in relieving uremic pruritus.

Page last updated: 2006-01-31

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