DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Comparison of candesartan with lisinopril on ambulatory blood pressure and morning surge in patients with systemic hypertension.

Author(s): Eguchi K, Kario K, Shimada K

Affiliation(s): Department of Cardiology, Jichi Medical School, Tochigi, Japan. kazuo-eg@jichi.ac.jp

Publication date & source: 2003-09-01, Am J Cardiol., 92(5):621-4.

Publication type: Clinical Trial; Randomized Controlled Trial

We performed a prospective crossover study in 73 essential hypertensives to compare the effects of candesartan and lisinopril on ambulatory blood pressure (BP) and early-morning BP. Twenty-four-hour ambulatory BP monitoring was performed at baseline and for each active treatment. Small doses of thiazide diuretic were added as needed. The effects of both drugs on 24-hour BP were almost identical and satisfactory. When we classified patients into the morning surge group (the highest quartile of morning systolic BP surge >36 mm Hg) and the non-morning surge group (the remaining 3 quartiles of morning BP surge), candesartan was superior in decreasing morning BP and morning BP surge.

Page last updated: 2006-01-31

-- advertisement -- The American Red Cross
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017