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Low testosterone concentrations and the symptoms of testosterone deficiency according to the Androgen Deficiency in Ageing Males (ADAM) and Ageing Males' Symptoms rating scale (AMS) questionnaires.

Author(s): Emmelot-Vonk MH, Verhaar HJ, Nakhai-Pour HR, Grobbee DE, van der Schouw YT

Affiliation(s): Department of Geriatrics Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands. m.h.emmelotvonk@umcutrecht.nl

Publication date & source: 2011-04, Clin Endocrinol (Oxf)., 74(4):488-94.

Publication type: Randomized Controlled Trial; Research Support, Non-U.S. Gov't

OBJECTIVE: First, to assess the association between the concentration of serum testosterone and the symptoms of testosterone deficiency according to two screening questionnaires. Second, to investigate the effects in elderly men with a low-normal testosterone concentration of testosterone supplementation over a period of 6 months on symptoms of testosterone deficiency according to the screening questionnaires. DESIGN, SETTING AND PARTICIPANTS: A total of 587 men between 60 and 80 years of age with an eligible serum testosterone measurement and completion of the screening questionnaires were included in the study. Of these 587 men, 237 men with testosterone levels <13.7 nmol/l were included in a double-blind, randomized, placebo-controlled trial of testosterone supplementation. INTERVENTION: One hundred and sixty milligrams per day of oral testosterone undecanoate or a matching placebo for 6 months. MEASUREMENTS: The Androgen Deficiency in Ageing Males (ADAM) and the Ageing Males' Symptoms rating scale (AMS) questionnaires. RESULTS: There was no significant association between the total testosterone concentration and the scores on the two questionnaires. However, age was significantly associated with the scores on the ADAM (OR 1.14, 95% CI 1.05-1.23) and the AMS (OR 1.03, 95% CI 1.01-1.08) questionnaire. After supplementation with testosterone, there were no effects on the scores on the two questionnaires in the testosterone group compared with the placebo group. CONCLUSION: The findings do not support the use of the ADAM or AMS questionnaire in the evaluation of late-onset hypogonadism in ageing men. Moreover, 6 months of oral testosterone supplementation had no significant effect on scores of the ADAM and AMS questionnaire in this group of elderly men with low-normal testosterone levels. (c) 2011 Blackwell Publishing Ltd.

Page last updated: 2011-12-09

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