DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more



Comparison of antihypertensive efficacy of carvedilol and nebivolol in mild-to-moderate primary hypertension: a randomized trial.

Author(s): Erdogan O, Ertem B, Altun A

Affiliation(s): Department of Cardiology, Faculty of Medicine, Marmara University, Istanbul, Turkey. okanerdogan@yahoo.com

Publication date & source: 2011-06, Anadolu Kardiyol Derg., 11(4):310-3. Epub 2011 May 5.

OBJECTIVE: The aim of the present study is to compare the antihypertensive effects of carvedilol and nebivolol in mild-to-moderate hypertensive patients. METHODS: It is a prospective; placebo-controlled, cross-over, double-blind, randomized, single-center clinical trial. Patients (n=20) who were first diagnosed with mild to moderate systemic hypertension according to mean ambulatory blood pressure measurements > 130/85 mmHg and no previous antihypertensive therapy were prospectively enrolled into the study. After 10 days of placebo run-in period, they were randomized within the same group as cross-over design to one month carvedilol 25 mg and one month nebivolol 5 mg regimen given once daily in the morning. The primary outcome variables were systolic and diastolic blood pressures determined by 24-hour ambulatory blood pressure measurements. Mutlivariate analysis of variance for repeated measurements with 3x2 factorial design was used for statistical analysis of results. RESULTS: The study group consisted of 6 women and 14 men whose mean age was 42.9+/-12.8 years (range 19-63 years). Mean heart rate was significantly decreased after commencing both carvedilol (70.2+/-5.2 bpm) and nebivolol (64.9+/-3.9 bpm) treatments compared to placebo (78.8+/-5.2 bpm) (p<0.05). Both carvedilol (133.8+/-9/86.6+/-8.6 mmHg) and nebivolol (134+/-8.7/85.6+/-7.4 mmHg) significantly decreased mean systolic and diastolic blood pressures compared to placebo (143.9+/-8.9/94.4+/-9.2 mmHg), respectively (p<0.05). However, there was no significant difference in decreasing either systolic or diastolic blood pressure between nebivolol and carvedilol therapies (p>0.05). No side effects were recorded during both carvedilol and nebivolol treatments. CONCLUSION: Although both carvedilol and nebivolol effectively decreased blood pressure compared to placebo, they showed similar efficacy for lowering blood pressure.

Page last updated: 2011-12-09

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017