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Recurrent herpes labialis: efficacy of topical therapy with penciclovir compared with acyclovir (aciclovir).

Author(s): Femiano F, Gombos F, Scully C

Affiliation(s): Stomatology Clinic, II, University of Medicine and Surgery, Napoli, Italy. femiano@libero.it

Publication date & source: 2001-01, Oral Dis., 7(1):31-3.

Publication type: Clinical Trial; Controlled Clinical Trial

This study compares the effects of topical acyclovir and penciclovir in the treatment of recurrent herpes labialis. The study patients were a population of 40 patients with in excess of five recurrences annually, and were separated into four homogeneous groups each of 10 subjects. The antiviral creams were used to achieve total lesional cover, every 2 h during waking hours. The effects on the time to lesion crusting and to resolution of pain, were assessed. The results not only confirmed that aciclovir is ineffective, but confirmed that penciclovir is effective, and that penciclovir is superior to aciclovir.

Page last updated: 2006-01-31

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