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Comparison of codeine phosphate and morphine sulphate in infants undergoing cleft palate repair.

Author(s): Fenlon S, Somerville N

Affiliation(s): Department of Anesthesia, Queen Victoria Hospital, West Sussex, UK.

Publication date & source: 2007-09, Cleft Palate Craniofac J., 44(5):528-31.

Publication type: Comparative Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

OBJECTIVE: To ascertain the quality of analgesia provided by morphine in comparison to codeine. DESIGN: The study is a prospective, randomized, double-blind trial of analgesic effect employing validated pain scores. PATIENTS: Infants having primary cleft palate repair with informed parental consent to enter the study. INTERVENTIONS: Infants received one of two analgesics intraoperatively for immediate postoperative pain relief. Morphine was given by intravenous injection and codeine by the intramuscular route. MAIN OUTCOME MEASURE: Pain scores in the immediate postoperative period for 2 hours following surgery; this outcome measure was decided prior to data collection. RESULTS: The pain score and other outcome measures were all blinded. Measurements are all evident from the nature of the results. CONCLUSIONS: There was no clinically significant difference observed in the analgesic effect of either drug on the two groups studied.

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