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Short-course therapy for right-side endocarditis due to Staphylococcus aureus in drug abusers: cloxacillin versus glycopeptides in combination with gentamicin.

Author(s): Fortun J, Navas E, Martinez-Beltran J, Perez-Molina J, Martin-Davila P, Guerrero A, Moreno S

Affiliation(s): Infectious Diseases Department, Hospital Ramon y Cajal, Madrid, Spain. fortun@mi.madritel.es

Publication date & source: 2001-07-01, Clin Infect Dis., 33(1):120-5. Epub 2001 Jun 5.

Publication type: Clinical Trial; Comparative Study ; Randomized Controlled Trial

A prospective, randomized clinical trial among drug abusers was conducted to assess the efficacy and safety of a short course of a combination of a glycopeptide (vancomycin or teicoplanin) and gentamicin compared with a combination of cloxacillin and gentamicin for treatment of right-side endocarditis caused by Staphylococcus aureus. Therapeutic success was significantly more frequent with cloxacillin than with a glycopeptide. No adverse effects were noted among patients in the cloxacillin group. A 14-day course of vancomycin or teicoplanin plus gentamicin is ineffective in this instance because it is associated with a high rate of clinical and microbiological failure.

Page last updated: 2007-10-18

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