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Electrical stimulation compared with tolterodine for treatment of urge/urge incontinence amongst women--a randomized controlled trial.

Author(s): Franzen K, Johansson JE, Lauridsen I, Canelid J, Heiwall B, Nilsson K

Affiliation(s): School of Health and Medical Sciences, Orebro University, Orebro, Sweden.

Publication date & source: 2010-12, Int Urogynecol J., 21(12):1517-24. Epub 2010 Jun 29.

Publication type: Randomized Controlled Trial

INTRODUCTION AND HYPOTHESIS: Few randomized controlled trials have compared electrical stimulation treatment with drug therapy. Our hypothesis was that electrical stimulation treatment in women with urgency/urge incontinence would be more efficient compared to drug treatment. METHODS: Women >/=18 years of age with urgency/urge incontinence were randomized to receive either ten electrical stimulation treatments vaginally and transanally over a period of 5-7 weeks or tolterodine 4 mg orally once daily. RESULTS: Sixty-one women completed the study. There was no significant difference between the two treatment groups in micturition rate from baseline to 6 months, mean difference, -0.40 (95% confidence interval (CI), -1.61 to 0.82), but a clearly significant difference within each group for electrical stimulation, -2.8 (95% CI, -3.7 to -1.9), and for tolterodine, -3.2 (95% CI, -4.1 to -2.4). CONCLUSIONS: Both treatments reduced the number of micturitions, but electrical stimulation was not found to be superior to tolterodine.

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