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Granisetron/dexamethasone combination for the prevention of postoperative nausea and vomiting after thyroidectomy.

Author(s): Fujii Y, Tanaka H, Kobayashi N

Affiliation(s): Department of Anaesthesiology, Toride Kyodo General Hospital, Ibaraki, Japan.

Publication date & source: 2000-06, Anaesth Intensive Care., 28(3):266-9.

Publication type: Clinical Trial; Randomized Controlled Trial

This study was undertaken to evaluate the efficacy of granisetron plus dexamethasone for preventing postoperative nausea and vomiting (PONV) after thyroidectomy. In a prospective, randomized, double-blind study, 130 female patients received either granisetron 40 micrograms/kg or granisetron 40 micrograms/kg plus dexamethasone 8 mg intravenously immediately before the induction of anaesthesia (n = 65 in each group). A standard general anaesthetic technique was used. A complete response (no PONV, no rescue) during the first three hours after anaesthesia occurred in 85% of patients with granisetron alone and 98% with granisetron plus dexamethasone; the corresponding incidence for the period 3 to 24 hours after anaesthesia was 86% and 98% (P < 0.05; Fisher's exact probability test). No clinically serious adverse events were observed in any of the groups. In conclusion, prophylactic use of granisetron/dexamethasone combination is more effective than granisetron alone for preventing PONV in women undergoing thyroidectomy.

Page last updated: 2006-01-31

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