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In vitro study of the potential role of quinupristin/dalfopristin in the treatment of catheter-related staphylococcal infections.

Author(s): Garcia R, Raad I

Affiliation(s): University of Texas M.D. Anderson Cancer Center, Department of Medical Specialties, Houston 77030, USA.

Publication date & source: 1996-12, Eur J Clin Microbiol Infect Dis., 15(12):933-6.

The susceptibility of clinical isolates of methicillin-susceptible and -resistant staphylococci from cancer patients with central venous catheter bacteremia to quinupristin/dalfopristin, a semisynthetic streptogramin, was determined in vitro. Susceptibility of these isolates to nine other antistaphylococcal antibiotics was also determined for comparison. A total of 197 staphylococcal strains were tested from 1983 to 1992. Quinupristin/dalfopristin was bactericidal against all isolates, independent of their resistance to methicillin. Its activity was similar to that of vancomycin but superior to that of teicoplanin. Quinupristin/dalfopristin may prove to be an important addition to our armamentarium against catheter-related staphylococcal infections.

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