Low-dose human chorionic gonadotropin versus estradiol/progesterone luteal phase support in gonadotropin-releasing hormone agonist-triggered assisted reproductive technique cycles: understanding a new approach.
Author(s): Garcia-Velasco JA, Motta L, Lopez A, Mayoral M, Cerrillo M, Pacheco A
Affiliation(s): IVI-Madrid, Madrid, Spain. jgvelasco@ivi.es
Publication date & source: 2010-12, Fertil Steril., 94(7):2820-3. Epub 2010 Jul 31.
Publication type: Randomized Controlled Trial
It remains unclear how GnRH agonist (GnRHa) triggering affects the luteal phase, so we investigated the luteal phase after GnRHa triggering, supported with conventional E(2)/P with or without low-dose hCG. E(2)/P support, compared with low-dose hCG, induced a shorter luteal phase (11.2 +/- 1.1 vs. 15.0 +/- 1.6 days) and fewer subjective complaints (0 vs. 42%), whereas hCG caused more free fluid accumulation and enlarged ovaries than E(2)/P alone. Steroids and low-dose hCG differentially affected corpus luteum function, ovarian size, free fluid accumulation, and patient comfort. Copyright (c) 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
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