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Low-dose human chorionic gonadotropin versus estradiol/progesterone luteal phase support in gonadotropin-releasing hormone agonist-triggered assisted reproductive technique cycles: understanding a new approach.

Author(s): Garcia-Velasco JA, Motta L, Lopez A, Mayoral M, Cerrillo M, Pacheco A

Affiliation(s): IVI-Madrid, Madrid, Spain. jgvelasco@ivi.es

Publication date & source: 2010-12, Fertil Steril., 94(7):2820-3. Epub 2010 Jul 31.

Publication type: Randomized Controlled Trial

It remains unclear how GnRH agonist (GnRHa) triggering affects the luteal phase, so we investigated the luteal phase after GnRHa triggering, supported with conventional E(2)/P with or without low-dose hCG. E(2)/P support, compared with low-dose hCG, induced a shorter luteal phase (11.2 +/- 1.1 vs. 15.0 +/- 1.6 days) and fewer subjective complaints (0 vs. 42%), whereas hCG caused more free fluid accumulation and enlarged ovaries than E(2)/P alone. Steroids and low-dose hCG differentially affected corpus luteum function, ovarian size, free fluid accumulation, and patient comfort. Copyright (c) 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

Page last updated: 2011-12-09

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