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Cerebrospinal fluid concentrations of quinupristin-dalfopristin in a patient with vancomycin-resistant Enterococcus faecium [correction of faecalis] ventriculitis.

Author(s): Garey KW, Tesoro E, Muggia V, Pasquier O, Rodvold KA

Affiliation(s): University of Illinois at Chicago, 60612, USA.

Publication date & source: 2001-06, Pharmacotherapy., 21(6):748-50.

Publication type: Case Reports

A 44-year-old man was treated successfully for vancomycin-resistant Enterococcus faecium (VREF) ventriculitis with intrathecal quinupristin-dalfopristin 1 mg, 2 mg, and 4 mg, and other intravenous antibiotics. Cerebrospinal fluid samples were collected before and after the 1-mg and 2-mg doses to determine the concentrations of quinupristin-dalfopristin and its active metabolites. Concentrations were above the minimum inhibitory concentration for VREF immediately after unclamping the extraventricular drain and were quantifiable for at least 7 hours.

Page last updated: 2006-01-31

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