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Estrogen therapy reduces nocturnal periodic limb movements.

Author(s): Hachul H, Baracat EC, Soares JM Jr, Haidar MA, de Mello MT, Tufik S, Bittencourt LR

Affiliation(s): Department of Medicine and Sleep Biology, Unifesp - Universidade Federal de Sao Paulo, SP, Brazil; Department of Gynecology, Unifesp - Universidade Federal de Sao Paulo, SP, Brazil.

Publication date & source: 2007-09-28, Maturitas., [Epub ahead of print]

It is believed that periodic limb movement (PLM) and more specifically, restless leg syndrome (RLS), are a common cause of insomnia. And one study in the literature examined PLM when associated to the use of estrogens. Polo-Kantola et al. [Polo-Kantola P, Rauhala E, Erkkola R, Irjala K, Polo O. Estrogen replacement therapy and nocturnal periodic limb movements: a randomized controlled trial. Obstet Gynecol 2001;97(4):548-54] observed that estrogen therapy improved subjective sleep quality regardless of periodic limb movements or related arousals. Herein is a case of a symptomatic postmenopausal patient with high PLM index who complained of insomnia and leg pain. Given that the patient had hot flashes and a high Kupperman Menopausal Index (which evaluates climacteric symptoms), we decided to administer transdermal ESTRADOT 25mug (Novartis, Brazil) twice-a-week. Our patient experienced a significant decrease in PLM as well as a great increase in REM and a slight increase in slow wave sleep (stages 3 and 4), as shown in the polysomnography. The patient reported an overall improvement in her condition.

Page last updated: 2007-10-18

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