Bupropion in adults with Attention-Deficit/Hyperactivity Disorder: a randomized,
double-blind study.
Author(s): Hamedi M(1), Mohammdi M(1), Ghaleiha A(2), Keshavarzi Z(1), Jafarnia M(1),
Keramatfar R(3), Alikhani R(1), Ehyaii A(1), Akhondzadeh S(1).
Affiliation(s): Author information:
(1)Psychiatric Research Centre, Roozbeh Hospital, Tehran University of Medical
Sciences, Tehran, Iran. s.akhond@neda.net. (2)Research Center for Behavioral
Disorders and Substance Abuse, Hamadan University of Medical Sciences, Hamadan,
Iran. s.akhond@neda.net. (3)Department of Psychiatry, AJA University of Medical
Sciences, Tehran, Iran. s.akhond@neda.net.
Publication date & source: 2014, Acta Med Iran. , 52(9):675-80
Attention-Deficit/Hyperactivity Disorder is one of the most common mental
disorders in childhood, and it continues to adulthood without proper treatment.
Stimulants have been used in the treatment of Attention-Deficit/Hyperactivity
Disorder (ADHD) for many years, and the efficacy of methylphenidate in the
treatment of adults with ADHD has been proven to be acceptable according to
meta-analysis studies. However, there are some concerns about stimulants. Finding
other effective medications for the treatment of adult ADHD seems necessary. We
hypothesized bupropion could be effective in the treatment of adult ADHD because
some theoretical and experimental evidence exists to support efficacy of this
medication. Forty-two patients with a diagnosis of ADHD, according to the revised
fourth edition of the Diagnostic and Statistical Manual of Mental Disorders, were
randomized to receive 150 mg/day bupropion or placebo for a 6-week double-blind,
placebo-controlled clinical trial. Each patient filled the Conners' Adult ADHD
Rating Scales-Self-Report-Screening version (CAARS) before starting to take
medication and in weeks 3 and 6 of the study. The mean score of the two groups
receiving bupropion or placebo decreased over the 6 weeks. There was a
significant difference between the two groups in CAARS score after 6 weeks.
Bupropion is more effective than placebo in the treatment of adults with ADHD.
Bupropion can be an alternative medication for the treatment of Adults with ADHD
as its clinical efficacy was proven by other studies.
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