Comparative efficacy of probiotic yoghurt and clindamycin in treatment of
bacterial vaginosis in pregnant women: a randomized clinical trial.
Author(s): Hantoushzadeh S, Golshahi F, Javadian P, Khazardoost S, Aram S, Hashemi S,
Mirarmandehi B, Borna S.
Affiliation(s): Maternal-Fetal & Neonatal Research Center and Breast Feeding Research Center,
Tehran University of Medical Sciences, Tehran, Iran. hantoushzadeh@tums.ac.ir
Publication date & source: 2012, J Matern Fetal Neonatal Med. , 25(7):1021-4
OBJECTIVE: This study was performed to determine the comparative efficacy of
probiotic yoghurt and clindamycin in the treatment of bacterial vaginosis in
pregnant women in the third trimester.
METHODS AND MATERIALS: This randomized clinical trial was performed as an
open-label study. 310 symptomatic patients with BV were recruited. Diagnosis of
BV was through Amsel criteria. The patients were randomly assigned to receive
either probiotic yoghurt (100 g twice a day/week) or orally administered
clindamycin (300 mg twice a day/week).
RESULTS: Ten patients in probiotic group and 9 subjects in clindamycin group had
symptom recurrence (p > 0.05). 132 patients in probiotic group and 105 subjects
in clindamycin group had pH decrease (p < 0.0001). 140 patients in probiotic
group and 141 subjects in clindamycin group had complete symptomatic cure (p >
0.05). Twelve patients in probiotic group and seven subjects in clindamycin group
had preterm birth. Nine women in probiotic group and five subjects in clindamycin
group had PROM (p > 0.05).
CONCLUSIONS: According to the obtained results, it may be concluded that
probiotics would have a good efficacy in the treatment of bacterial vaginosis in
pregnancy leading to decreased burden of subsequent preterm birth.
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