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Randomized, multicenter comparison of oral granisetron and oral ondansetron for emetogenic chemotherapy.

Author(s): Herrington JD, Kwan P, Young RR, Lagow E, Lagrone L, Riggs MW

Affiliation(s): Department of Pharmacy, Scott & White Memorial Hospital, Temple, TX 76508, USA.

Publication date & source: 2000-11, Pharmacotherapy., 20(11):1318-23.

Publication type: Clinical Trial; Multicenter Study; Randomized Controlled Trial

STUDY OBJECTIVES: To compare the antiemetic effectiveness and safety of oral granisetron plus dexamethasone with those of oral ondansetron plus dexamethasone administered before emetogenic chemotherapy. DESIGN: Randomized, prospective, multicenter, open-label study. SETTINGS: University-teaching hospital and veterans health care system. PATIENTS: Sixty-one chemotherapy-naive patients scheduled to receive emetogenic antineoplastic agents. INTERVENTION: A single-dose oral granisetron 1 mg and dexamethasone 12 mg or single-dose oral ondansetron 16 mg and dexamethasone 12 mg was administered before chemotherapy. MEASUREMENTS AND RESULTS: Twenty-four hours after administration patients were contacted to assess nausea, emesis, and adverse events. There were no statistical differences in frequency of nausea or emesis between groups. Seventy-six percent and 82% of patients receiving ondansetron and granisetron, respectively, experienced no emesis 24 hours after chemotherapy. Complete protection from nausea occurred in 58% and 46% of patients receiving the drugs, respectively. Adverse events were similar between groups. CONCLUSION: Oral granisetron 1 mg and ondansetron 16 mg plus dexamethasone are safe and effective in preventing nausea and vomiting related to emetogenic chemotherapy.

Page last updated: 2006-01-31

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