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Phentolamine mesylate for accelerating recovery from lip and tongue anesthesia.

Author(s): Hersh EV, Lindemeyer RG

Affiliation(s): Department of Oral Surgery and Pharmacology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104-6030, USA. evhersh@pobox.upenn.edu

Publication date & source: 2010-10, Dent Clin North Am., 54(4):631-42.

Publication type: Research Support, Non-U.S. Gov't; Review

Phentolamine mesylate, at dosages from 0.4 to 0.8 mg in adults and adolescents and at dosages from 0.2 to 0.4 mg in children aged 4 to 11 years, has been proven to be safe and effective for the reversal of soft tissue anesthesia (lip and tongue numbness) and the associated functional deficits resulting from a local dental anesthetic injection containing a vasoconstrictor. Its ability to block a-adrenergic receptors on blood vessels induces vasodilation and enhances the redistribution of the local anesthetic away from the injection site. The low dosages administered for dental local anesthetic reversal in all likelihood accounts for the lack of significant cardiovascular effects that are associated with the medical use of the drug for hypertensive conditions associated with catecholamine excess. Copyright (c) 2010 Elsevier Inc. All rights reserved.

Page last updated: 2011-12-09

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