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Effect of transdermal hyoscine on nausea and vomiting during and after middle ear surgery under local anaesthesia.

Author(s): Honkavaara P

Affiliation(s): Department of Anaesthesia, Otolaryngological Hospital, University of Helsinki, Finland.

Publication date & source: 1996-01, Br J Anaesth., 76(1):49-53.

Publication type: Clinical Trial; Randomized Controlled Trial

The efficacy of transdermal hyoscine in the reduction of nausea, retching and vomiting was compared with placebo during and after stapedo- and tympanoplasty under local anaesthesia in a double-blind, prospective and randomized study. In the placebo group (n = 29), 69% of the patients were free from emetic symptoms during and 41% after the operation. The corresponding figures were 93% (P < 0.05) and 74% (P < 0.05) in the hyoscine group (n = 27). The patients in the placebo group needed more droperidol during and after operation (P < 0.05). The frequency of side effects was similar in both groups. In posturography the patients with emetic sequelae in the placebo group had a markedly deteriorated upkeep of posture (P < 0.05) measured as body sway velocities. A strong correlation was found between motion sickness and emetic sequelae after surgery, and patients with a history of motion sickness benefited most from hyoscine.

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