DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Effect of low dose dopamine on early graft function in living unrelated kidney donors.

Author(s): Hosseinzadeh H, Golzari S, Abravesh M, Mahmoodpoor A, Aghamohammadi D, Zomorrodi A, Hosseinzadeh P.

Affiliation(s): Department of Anesthesiology, Imam Khomeini Hospital, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Publication date & source: 2012, Urol J. , 9(1):389-96

PURPOSE: To evaluate the effect of low-dose dopamine administration on the early function of the kidney in unrelated kidney donors after transplantation. MATERIALS AND METHODS: In this double-blinded clinical trial, 60 adult kidney donors and 60 recipients, younger than 50 years old, were studied. Donors and recipients were randomly divided into two groups; group 1 received dopamine 3 µ/kg/min and group 2 received similar regimen of placebo. During the first 3 days postoperatively, serum levels of urea and creatinine as well as urine output and early kidney function were compared between two groups. RESULTS: Serum levels of creatinine and urea and urine output during the first three days after the operation did not differ statistically significantly between two groups (P = .549, P = .306, and P = .375, respectively). Early kidney function was better significantly in group 1 (5.3 ± 3.2 versus 8.6 ± 8.0 hours; P = .048). CONCLUSION: Premedication of the kidney transplant donors with low-dose dopamine accelerates early kidney function after transplantation, but has no effect on the hemodynamic status and serum levels of creatinine and urea in the donors.

Page last updated: 2013-02-10

-- advertisement -- The American Red Cross
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017