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The optimal dose of nicardipine for enhancement of indirect portography.

Author(s): Inoue Y, Nakamura H, Akaji H

Affiliation(s): Department of Radiology, Minoo City Hospital, 5-7-1 Kayano, Minoo, Osaka 562, Japan.

Publication date & source: 1998-01, Cardiovasc Intervent Radiol., 21(1):17-21.

Publication type: Clinical Trial; Randomized Controlled Trial

PURPOSE: To determine the optimal dose of nicardipine (NCR) for enhancement of indirect portography. METHODS: Forty-eight patients underwent conventional film indirect portography via the superior mesenteric artery (SMA) first without and then with preinjection of 1/64-2 mg of NCR into the SMA. RESULTS: NCR (1/8-2 mg) shortened the arterial phase to 50% and the portal appearance time to 60% of control without reflux of contrast medium into the aorta. Portal enhancement was excellent at doses of 1/32 mg or more. Blood pressures and pulse rate showed no significant change at 1/4 mg or less. CONCLUSION: NCR (1/8-1/4 mg) into the SMA is the optimal dose for achieving sufficient contrast enhancement on indirect portography while reducing the transit time of contrast medium and minimizing effects on the systemic circulation.

Page last updated: 2006-01-31

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