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24-Hour Efficacy and Safety of Triple-Combination Therapy With Olmesartan, Amlodipine, and Hydrochlorothiazide: The TRINITY Ambulatory Blood Pressure Substudy.

Author(s): Izzo JL Jr, Chrysant SG, Kereiakes DJ, Littlejohn Iii T, Oparil S, Melino M, Lee J, Fernandez V, Heyrman R

Affiliation(s): From the State University of New York at Buffalo, Buffalo, NY;Oklahoma Cardiovascular and Hypertension Center and University of Oklahoma College of Medicine, Oklahoma, OK;the Christ Hospital Heart and Vascular Center and The Carl and Edyth Lindner Center for Research and Education at the Christ Hospital, Cincinnati, OH;Piedmont Medical Research Associates, Winston-Salem, NC;the University of Alabama at Birmingham, Birmingham, AL;Daiichi Sankyo, Inc, Parsippany, NJ.

Publication date & source: 2011-12, J Clin Hypertens (Greenwich)., 13(12):873-80. Epub 2011 Oct 28.

J Clin Hypertens (Greenwich). 2011;13:873-880. (c)2011 Wiley Periodicals, Inc. This 12-week, multicenter, randomized, double-blinded, 4-arm study in 440 patients with moderate to severe hypertension compared ambulatory blood pressure (ABP) responses with a triple-combination regimen (olmesartan medoxomil [OM] 40 mg, amlodipine besylate [AML] 10 mg, and hydrochlorothiazide [HCTZ] 25 mg) and its component dual-combination regimens at similar doses. At week 12, the triple combination resulted in a greater reduction in mean 24-hour systolic and diastolic blood pressure (-30.3/-18.0 mm Hg) compared with the 3 dual-combination regimens (OM 40 mg/AML 10 mg: -23.5/-13.9, OM 40 mg/HCTZ 25 mg: -23.9/-14.5, and AML 10 mg/HCTZ 25 mg: -18.5 mm Hg/-10.7 mm Hg; P<.0001 each). Greater efficacy was also found during daytime and nighttime hours and during the last 6, 4, or 2 hours of the dosing interval. The authors conclude that the triple combination of OM 40 mg/AML 10 mg/HCTZ 25 mg demonstrated superior efficacy and sustained reductions in ABP compared with its dual-combination components. (c) 2011 Wiley Periodicals, Inc.

Page last updated: 2011-12-09

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