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Effect of pretreatment prednisolone on postendodontic pain: a double-blind parallel-randomized clinical trial.

Author(s): Jalalzadeh SM, Mamavi A, Shahriari S, Santos FA, Pochapski MT

Affiliation(s): Department of Endodontics, University of Medical Sciences, Hamadan, Iran.

Publication date & source: 2010-06, J Endod., 36(6):978-81. Epub 2010 Apr 24.

Publication type: Comparative Study; Randomized Controlled Trial

INTRODUCTION: Effective management of endodontic pain represents a continuing challenge. This study evaluates the use of a preoperative, single oral dose of prednisolone for the prevention and control of postendodontic pain. METHODS: Forty patients were randomly assigned to 2 groups, placebo and prednisolone (30 mg). The medications were administered 30 minutes before the start of standard endodontic treatment. Postoperative pain was assessed after 6, 12, and 24 hours by using a visual analogue scale. RESULTS: The outcome showed that prednisolone resulted in a statistically significant reduction in postendodontic pain at 6, 12, and 24 hours (P < .0001). No side effects were reported for any of the medications used. CONCLUSIONS: This study suggests that a preoperative, single oral dose of prednisolone substantially reduced postendodontic pain. Further studies are needed to evaluate the applicability of these findings to other clinical conditions, single- versus multiple-visit endodontic treatment, and drug regimens. Copyright 2010 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

Page last updated: 2010-10-05

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