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A pilot randomized, double-blind, placebo-controlled study of granisetron in the treatment of sexual dysfunction in women associated with antidepressant use.

Author(s): Jespersen S, Berk M, Van Wyk C, Dean O, Dodd S, Szabo CP, Maud C

Affiliation(s): Department of Psychiatry, University of Witwatersrand Medical School, Parktown, South Africa.

Publication date & source: 2004-05, Int Clin Psychopharmacol., 19(3):161-4.

Publication type: Clinical Trial; Randomized Controlled Trial

A pilot study was conducted to evaluate the usefulness of granisetron for the treatment of antidepressant induced sexual dysfunction in women. Twelve women with antidepressant induced sexual dysfunction (AISD) were assigned granisetron (n=5) or placebo (n=7) in a 14-day randomized, double-blind, placebo-controlled study. One participant in the granisetron group did not complete the study. Participants were assessed at baseline, day 7 and day 14 using the Feiger Sexual Function and Satisfaction Questionnaire and the Arizona Sexual Experience Scale. No statistical differences were measured at baseline or at endpoint between the granisetron or placebo group. This study did not produce evidence supporting the usefulness of granisetron in AISD.

Page last updated: 2006-01-31

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