Once-daily naftifine cream 1% in the treatment of tinea cruris and tinea corporis.

Author(s): Jordon RE, Rapini RP, Rex IH Jr, Katz HI, Hickman JG, Bard JW, Medansky RS, Lew-Kaya DA, Sefton J, DeGryse RE

Affiliation(s): Department of Medicine, University of Texas Health Science Center, Houston.

Publication date & source: 1990-07, Int J Dermatol., 29(6):441-2.

Publication type: Clinical Trial; Randomized Controlled Trial

Seventy patients with tinea cruris or tinea corporis were treated with naftifine cream 1% or vehicle once daily for 4 weeks in this double-blind, randomized study. After two weeks, the patients using naftifine had a significantly higher mycologic cure rate than the vehicle-treated patients (79% vs. 31%, p less than 0.001), and they showed significantly better resolution of signs and symptoms. Statistically significantly differences favoring naftifine over its vehicle were found throughout the treatment period and 2 weeks posttreatment.