Ondansetrone or metoclopromide? Which is more effective in severe nausea and
vomiting of pregnancy? A randomized trial double-blind study.
Author(s): Kashifard M(1), Basirat Z, Kashifard M, Golsorkhtabar-Amiri M, Moghaddamnia A.
Affiliation(s): Author information:
(1)Department of Internal Medicine, Babol University of Medical Science, Babol,
Iran.
Publication date & source: 2013, Clin Exp Obstet Gynecol. , 40(1):127-30
BACKGROUND: Nausea and vomiting of pregnancy (NVP) are seen in 50-80% of
pregnancies. However, in severe NVP, called hypermesis gravidarum (HG), medical
therapy to reduce nausea and vomiting is inevitable and ondansetron (OND) as an
effective drug has recently been proposed. This study evaluated the effectiveness
of OND versus metoclopramide (MET) in the treatment of HG.
METHODS: In this clinical trial study, 83 pregnant women with HG were enrolled in
2011-2012 and randomly divided in two groups. The first group received oral
administration of MET and the second group was treated with OND for two weeks.
Severity of nausea and vomiting were evaluated according to visual analogue scale
(VAS) criteria. Data analysis was done by chi2, Fisher exact test and Student's
t-test.
RESULTS: Comparison of the trend of change of vomiting in the two groups during
the 14-day treatment showed the OND group had significantly lower vomiting scores
versus the MET group (p = 0.042), while there was no significant difference in
the trend of nausea.
CONCLUSION: OND has a more favorable effect in controlling severe vomiting.
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